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Sodium nitrite should be administered first, followed immediately by sodium thiosulfate

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But it also raises IGF-1, disrupts glucose metabolism, and can accelerate unwanted tissue growth

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Tesofensine should not be used in those with: Uncontrolled hypertension Serious cardiac arrhythmias History of stroke Bipolar disorder or untreated anxiety As with any weight loss medication, it should be used under physician supervision