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As is the case for HIV non-infected persons, these decisions are influenced by the results of the liver biopsy interpreted in light of other factors that might reduce the benefits of treatment (such as the stage of HIV infection oralcohol use) and co-morbid conditions (such as depression) that might increase treatment toxicity

Melanotan II has a longer half-life than native -MSH ( ~30 minutes in plasma ), but the biological pigmentation effect persists for days due to activation of melanogenesis in melanocytes