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En pratique, la toxicit de la vitamine B12 reste extrmement faible, mme des doses leves

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In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyltetrahydrofolate, and a functional folate deficiency occurs

52-Week Study: Long-Term Safety and Tolerability A Phase 3, single-arm, open-label study assessed the long-term safety, tolerability, and efficacy of 24-hour continuous subcutaneous infusion of PRODUODOPA over 52 weeks in 244 patients with advanced PD