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Metabolomic profiling of ZrO 2 nanoparticles in MC3T3-E1 cells

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Complement Ther Med (2019) 43:25360

demonstrated that PET NPs (size and dose not reported) can skew the immune balance towards a pro-inflammatory phenotype (shift to Th1/Th17), disrupt immune regulation by decreasing Treg cells and IL-2, and potentially contribute to the development of immune-mediated disorders through increased secretion of pro-inflammatory cytokines and reduced regulatory signalling [87]