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In some patients, the immune response leads to viral destruction and downregulation of inflammation, while others generate a severe proinflammatory hypercytokinemia, multisystem inflammation, and shock, with some patients developing respiratory failure requiring mechanical ventilation [52] (Figure 1)

doi: 10.1111/j.1600-0897.2010.00831.x 365 CollierAYModestAMAguayoRABondzieEAPatelSHackerMRet al