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Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms

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Try eating at least one orange daily to improve your health

These mutations therefore disproportionately affect individuals with ancestry from malaria endemic regions, namely Africa, the Middle East, Southeast Asia, and the Mediterranean

Oral and IV glutathione are not interchangeable in terms of dose or systemic exposure