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Description
DAnna R, Scilipoti A, Giordano D, et al
The push is administered slowly over 10-15 minutes to prevent any adverse reactions
The mechanism is straightforward but powerful
1,2 In its active conformation, the enzyme catalyzes -KG and NADPH production and then either remains in its active conformation (continuing to catalyze the isocitrate decarboxylation) or returns to its inactive conformation (restoring the Ser94-Asp279 interaction)
Raising GH is therefore mechanistically distinct from administering an IGF-1 analog, even though both ultimately touch IGF-1 receptor signaling
