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Genetic predisposition, proteomics, neurotransmitter and biological system mechanisms are likely to link vitamin D to RLS (see Figure 1)
Thomas Jefferson University 18th Annual Spine Fellowship meeting, Newport, RI, 7/13-14, 2018 Chairman
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Changes in key enzymes in the phenylpropanoid biosynthesis pathway (such as POD, CAD, and PAL) can influence the activity of the entire pathway
They migrate more efficiently toward damaged areas and begin synthesizing new collagen matrix upon arrival
In these cases, B 12 deficiency is mostly only moderate
