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Description
determined that ferroptosis is a key mechanism underlying blood-retinal barrier damage in diabetic retinopathy, demonstrating that Flotillin-1 activates the Nrf2 pathway by enhancing its expression and promoting its nuclear translocation, thereby stimulating the SLC7A11/GPX4 pathway to inhibit lipid peroxidation and ferroptosis [168]

This can lead to the accumulation of amyloid plaque, which triggers the brain and exposes it to oxygen stress and inflammation

Yamakita, S

(l) study protocols

The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus