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Invest Dermatol

Figure 1.Water composition of tissues and organs by weight

Key Mechanisms of Action Stimulates lipolysis: AOD-9604 increases the breakdown of stored triglycerides into free fatty acids, making them available for energy use Inhibits lipogenesis: It reduces the activity of enzymes responsible for creating new fat tissue, effectively slowing the bodys ability to store excess energy as fat Enhances fat oxidation: By promoting fatty acid utilization, AOD-9604 encourages the body to shift toward burning fat as a primary energy source, especially in combination with diet and exercise

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Additionally, a higher expression of programmed death 1 (PD-1) on NK membranes and the binding to its ligand on MM cells contribute to the impaired immune response and MM progression [41]
