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Neurological symptoms represent a significant concern with B12 deficiency and may include: Paraesthesia (pins and needles) in the hands and feet Difficulty with balance and coordination Memory problems or cognitive changes Mood disturbances , including depression or irritability Glossitis (sore, red tongue) and mouth ulcers Haematological manifestations of B12 deficiency include megaloblastic anaemia , characterised by the production of abnormally large, immature red blood cells

For people with an MTHFR mutation, methylcobalamin (as opposed to other forms of B12) is therapeutic

Their diet may not be as good for absorbing B12

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The key difference comes down to bioavailability, which is how much of a nutrient your body can actually absorb and use