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Environ Int 102:8796

A future study of the mechanism by which MOTS-c enters cells will be of great importance in order to determine how it exerts its clinical therapeutic effect

FD is more common in females than males (as is typical for FND in general) and has a typical age of onset of 2950 years, depending on the population tested, compared to a generally childhood, adolescent or early adult-onset in most genetic dystonias (Table 2 ( Table 2 The biopsychosocial model: predisposing, precipitating, and perpetuating factors for the development and maintenance of functional dystonia and related functional neurological disorders [adapted from McKee et al

However, as ammonia accumulates to higher concentrations, it may disrupt the initiation and degradation stages of autophagy (e.g., inhibiting autophagosome-lysosome fusion), impairing autophagic flux and promoting autophagic cell death (109, 115)

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