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Study shows that treatment with GSK864 as IDH1 inhibitor binding an allosteric site on IDH1 reduces the NADPH/NADP + ratio and prolongs the survival of glioblastoma multiforme (GBM) PDXs model

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In addition, arginine, one of the core substrates of GM, regulates immune cells by affecting M1/M2 macrophage polarization

Although the dopamine receptor agonists play an important role in PD symptomatic treatment, prolonged usage of dopamine receptor agonists causes side effects such as drowsiness, illusions, orthostatic hypotension, compulsive eating, weight gain, and edema [144,145,146]