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Contraction of the ciliary muscle facilitates opening of the trabecular meshwork via the scleral spur, thereby increasing aqueous humor outflow and reducing IOP, while pupillary constriction can contribute to angle opening in eyes with narrow or occludable angles

For example, doxorubicin (DOX) has cardiac side effects that lead to irreversible dilated cardiomyopathy and congestive heart failure, and acetylcarnitine has been shown to prevent cardiac functional and structural damage caused by DOX-induced oxidative stress [289]

However, vascular effects could not be considered as the primary event in NSAID-mediated gastric mucosal damage [19]

Cells overexpressing GCH1 were found to possess two polyunsaturated fatty acyl chains, a structural feature that significantly protects against the depletion of PUFAs in ferroptosis, serving as a physical defense mechanism against ferroptosis (76)

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