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Several lines of evidence indicated that SIRT3 deacetylates long-chain acyl-CoA dehydrogenase (LCAD), a critical enzyme for long-chain FA degradation, and carnitine palmitoyltransferase 2 (CPT2), a key enzyme for FA transfer, to enhance FAO [28,29,30,31]

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These processes may exist in combination and at different intensities in different patient subgroups