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Active enhancers are marked by H3K4 Me1/2 which is catalyzed by MLL3/4 and removed by LSD1 (KDM1) and LSD2 (KDM2)
Additionally, the exposure to pesticides like rotenone or 1-methyl-4-phenylpyridinium (MPP + ) and heavy metals (manganese) increases the risk of PD development [6, 10, 14-15]
9 , 6057 (2003) A
