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The major pathological hallmarks of PD are represented by the progressive loss of dopamine(DA)-ergic neurons in the substantia nigra (SN) of the central nervous system (CNS) associated with cytoplasmic inclusions termed as Lewy bodies and Lewy neurites (Spillantini et al., 1997)

These are available at The following three imageJ macro scripts are required: 00-Preporcessing 01-Anisotropy Macro 03-ROI Selection The images were background-corrected using a rolling ball filter where the radius is larger than the largest cell in your images but small enough that distortions in the background are removed, in this case a radius of 100 was used

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The clinical application of responsive nanomaterials must undergo rigorous regulatory review and approval