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doi: 10.1016/j.ekir.2017.11.020, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 145

Bottom line: Diffuse neuromodulator, no clear receptor, no clear tolerance signal
In fact, it is essential for a healthy pregnancy

Sydow et al

Collagen is found in bone broth, fish with skin, and connective tissues of animals