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Moreover, the eyes delicate immune privilege presents challenges for therapeutic interventions, as excessive immune suppression could disrupt local immune homeostasis, thereby heightening the risk of infections or neoplastic transformations

(CRC Press, 1987)

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Beyond the immediate nerve injury, the surgical environment itself contributes through associated factors like the intensity of acute postoperative pain, which acts as a potent nociceptive barrage driving central sensitization, and potentially inadequate perioperative analgesia [4]