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4) upregulating MMPs such as MMP-2, MMP-9, and MMP-13, while downregulating TIMPs, including TIMP-1 and TIMP-2, to promote ECM degradation [78, 79]

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Regulatory status : Neither peptide is approved for therapeutic use in humans

4-(Diethylamino)benzaldehyde 4-(Diethylamino)benzaldehyde (DEAB) seems to be more of a slow competitive substrate (like citral and chloral) than a classic inhibitor of ALDH isozymes (Russo et al., 1988), although the precise mechanism of inhibition remains to be elucidated

Methylseleninic acid downregulates hypoxia-inducible factor-1 in invasive prostate cancer