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Nature Chemical Biology 9(5):300-306

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The molecular mechanisms underlying 5-amino-1MQ's anti-adipogenic effects involve complex interactions between NAD+ metabolism, methylation status, and transcriptional regulation

5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame