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Oxidative stress primarily refers to the process of oxidative damage resulting from an imbalance between oxidative and antioxidant systems in cells and tissues, leading to the accumulation of free radicals and ROS (41)

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In particular, the mitochondrial inner membrane is impermeable to fatty acyl-CoA thioesters and, thus, the specialized CS, for transporting fatty acids across mitochondrial membranes has evolved 18

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