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Epithalon is a synthetic four-amino-acid peptide (alanine-glutamic acid-aspartic acid-glycine, or AEDG) modeled on epithalamin, a compound made by the pineal gland

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While heterologous desensitization of the 2 AR was mediated primarily by PKA, a novel catecholamine-activated cAMP-independent kinase, termed AR kinase (ARK, later named GRK2), was responsible for the process of homologous desensitization [11, 12]