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1 Introduction The thyroid tumor is the most common endocrine tumor

Under stress or pathological conditions, endogenous serine production may be insufficient to meet cellular demands

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

Deuse, T

A global burden assessment of lung cancer attributed to residential radon exposure during 19902019