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Genistein is capable of inducing apoptosis of Bcl-2-silenced malignant neuroblastoma cells by both ligand- (Fas ligand/TNF-related apoptosis-inducing ligand) death receptor- (Fas/TNF receptor) mediated extrinsic and mitochondria-dependent intrinsic pathways [155]

However, KD failed to improve motor performance in the rotarod test or prevent brain atrophy, indicating that while KD may modulate metabolic aspects, it does not appear to fully prevent neurodegeneration in transgenic HD mice [98]

10.1016/j.cell.2017.07.032 10.1016/j.cell.2017.07.032 [DOI] [PMC free article] [PubMed] [Google Scholar] Creagan ET, Moertel CG, O'Fallon JR et al (1979) Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer

Sagittaria sagittifolia polysaccharide protects against isoniazid- and rifampicin-induced hepatic injury via activation of nuclear factor E2-related factor 2 signaling in mice

CDK4 and CDK6 control the cell cycle transition from G1 phase to S phase, and inhibiting their expression halts tumor cell proliferation and induces apoptosis directly