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When 5 mg human BDNF was injected intravitreally after H/R, the number of TUNEL- and caspase-2-positive cells in the BDNF-treated group vs

Enzymatic degradation: Proteases in blood and tissues degrade peptides reducing bioavailability

261 They have shown potentials in pre-clinical study in different animal models of CNS diseases demonstrating attractive properties for drug delivery including controlled drug release, cellular targeting and uptake, and the ability to avoid phagocytosis of reticuloendothelial system
Epub 2020 Jul 1 PMID: 32622022
