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If a drug undergoes selective metabolism by UGT1A1, competition for drug metabolism with bilirubin glucuronidation will exist, resulting in pronounced hyperbilirubinemia as well as reduced clearance of the metabolized drug

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when the intracellular Fe2+ overload exceeds the caching capacity of ferritin, and intracellular free iron generates ROS through the fenton reaction, and glutathione (GSH), one of the critically important antioxidants in cells, is catalyzed by peroxidase to oxidized glutathione (GSSG) during lipid peroxidation, and inhibit lipid peroxidation-induced ferroptosis (119)

Does your body run low on essentials that keep cells firing

R., Denhardt, D