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Cell sensitivity assays: the MTT assay
Applications include the identification of biomarkers for earlier diagnosis of disease and biomarkers of drug-target engagement that can be used for the development and testing of new therapies

J Biol Chem 274:1950919512

Thus, in the absence of a healthy glycocalyx, excess sodium ions enter endothelial cells and activate cell signaling pathways that positively regulate production of F-actin cytoskeletal fibers (85)