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10.1101/lm.039222.115 Learn
The exact signaling pathway of PPAR in UF has not been clearly characterized despite the fact that PPAR protein isoforms are expressed at higher levels in UF (Tsibris et al., 1999) or a relatively equal level as compared to the normal myometrium (Nam et al., 2007), downregulation of cyclooxygenase-2 (COX-2), and caspase-3 activation (Liu et al., 2007)
The binding of ligands, including cytokines and growth factors, induces a conformational change that activates JAK
Source:PubMed
