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& Nakanuma, Y

Oncogene 39 , 21562169 (2020)

To investigate the influence of gut microbiota on the distribution and biotransformation of curcumin, we used C57BL/6J mice as animal models and established a gut dysbiosis model using the third-generations broad-spectrum antibiotic ceftriaxone sodium, followed by curcumin treatment

In certain embodiments, the subject may be a subject having a baseline intracellular level of GSH, tGSH, or both, when compared to children without a diagnosis of autism (it has previously been found that plasma, intracellular, and even brain levels of GSH may be decreased compared to control children without autism

Challenges in Stability, Delivery, and Toxicity Although AMPs hold great promise for the treatment of bacterial infections, the clinical use is encumbered by several major challenges, the most significant of which pertain to their susceptibility to host and bacterial proteolytic enzymes, thereby affecting their stability and diminishing their therapeutic half-life [177]