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Over time, this chronic immune activation may contribute to fatigue, cognitive changes, digestive disruption, respiratory symptoms, metabolic instability, and heightened inflammatory sensitivity
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This is also consistent with the long understood paradox that NRF2 deficiency may increase susceptibility to carcinogenesis whereas increased NRF2 activity in an already developed tumor supports many of the hallmarks of cancer progression and survival [48]
& Schluesenner, H
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