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People with kidney disease B12 injections may stress already-compromised kidney function

The purpose of this study was to determine whether nicotinamide (NAM), an NAD + precursor, can support the maintenance of bone homeostasis by regulating osteoblasts

Gorman, GS, Chinnery, PF, DiMauro, S, Hirano, M, Koga, Y, McFarland, R, Suomalainen, A, Thorburn, DR, Zeviani, M, Turnbull, DM 2016, Mitochondrial diseases, Nature Reviews Disease Primers , vol

That's both the opportunity and the trap: at these prices, the cost difference between a well-tested vial and a poorly tested one is trivial, so there's no reason to accept anything less than a verified COA

Proc Natl Acad Sci U S A 119(8):e2107266119