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Specifically, prolonged inhibition of KGDHC in both neuroblastoma cells and primary neurons has been shown to enhance the calcium response to potassium-induced depolarization by approximately 2843% following 24 to 48 h of treatment (Gibson et al., 2012)

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The methylation status of the tRNA Sec is dependent on selenium status, and the presence of the ribosyl methylation regulates the efficient translation of a subset of selenoprotein transcripts, including GPx1
