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The brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), are essential and common mechanisms for the antidepressant effects of both the parent molecules of ketamines [i.e., S, R()ketamine, S(+)ketamine, and R()ketamine] and their active metabolites [i.e., (2R,6R)-hydroxynorketamine and of S(+)norketamine] (Yang et al., 2019)

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Guo J, Tang W, Liu W, Zhang Y, Wang L, Wang W

and royalties from Wolters Kluwer Health, Guilford Press and the University of Texas Southwestern Medical Center, Dallas, TX (for the Inventory of Depressive Symptoms and its derivatives)