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The combination of skin-lightening agents with vitamins and UV filters has also been shown to improve skin hyperpigmentation [52], as shown in a study on melasma treatment comparing a cream containing 4% hydroquinone, 10% buffered glycolic acid, vitamins C and E, and UV filters with a UV-only sunscreen [202]

10.1111/acn.12016 406 SorboniS

Hence, it is logical to hypothesize that masking of the terminal NH 2 group by making a labile chemical derivative of INH, i.e., a derivative which can release INH back when exposed to biofluid in gut or blood (owing to hydrolytic activity of esterase/amidase) can limit known metabolic biotransformations of INH (Figure 6)

Inhibition of NNMT has been shown to reduce fat accumulation and increase energy expenditure in preclinical models

[DOI] [PubMed] [Google Scholar] 119.Deleuran M., Dzfoulian B., Elberling J., Knutar I., Lapeere H., Lossius A.H., Schuttelaar M.L.A., Stockman A., Wikstrm E., Bradley M., et al