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Neuron (2013) 78(1):13851
This coexpression technology, SNORCL, is an example of how the functional diversity of oxygen-related enzymes in all kingdoms of life can be taken advantage of for oxygen delivery if appropriate candidates are identified

doi: 10.1165/ajrcmb.20.2.3305

For example, loss of Purkinje cells leads to anterograde trans-synaptic degeneration of cerebellar nuclei and retrograde trans-synaptic degeneration of cerebellar granule cells