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It means that single lever thinking often creates disappointment
Sampaio, J
Analysis of the reactivity of the cysteines in p53 by mass spectrometry revealed preferential reaction with C124 and C141, followed by C135, C182, and C277, and then C176 and C275 ( Among the 10 cysteine residues in p53s core domain, four Cys182, Cys229, Cys242, and Cys277 are exposed on the surface of the protein and accessible for modification in correctly folded p53 ( Thus, APR-246/MQ, MIRA-1 and the compounds identified by Kaar et al
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10.1152/ajpregu.00506.2012 15
