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During tumor progression, macrophage-derived TGF-1 can inhibit transcription through SMAD signaling, thereby promoting ferroptosis (85) and thus representing a complex interplay between immunosuppressive cytokines and ferroptotic mechanisms

Many tumor suppressor genes are inactivated by this mechanism in cancer such as the adenomatous polyposis coli (APC) [29], retinoblastoma (Rb) [30], Von Hippel-Lindau (VHL), BRCA1 [31], and several other genes that are involved in DNA repair (MGMT

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