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Description
Glutathionuria: inborn error of metabolism due to tissue deficiency of gamma-glutamyl transpeptidase
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Such extranuclear mtDNA acts as a potent DAMP, capable of activating innate immune sensors including cGAS, TLR9, and the NOD, LRR and pyrin domain-containing protein 3 (NLRP3) inflammasome, thus triggering neuroinflammatory cascades [32,33,34]
The GSTM1 gene contains four alleles and has been the most widely studied (Table 5)
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