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Box: Hydroxocobalamin dosing schedule for the management of pernicious anaemia If no neurological involvement: Loading dose: 1,000 micrograms three times per week for two weeks Maintenance dose: 1,000 micrograms every two to three months If neurological involvement: Loading dose: 1,000 micrograms every other day until no further improvement Maintenance dose: 1,000 micrograms every two months Injections are usually administered at a GP surgery, although some patients can be taught to self administer[22]

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After detailed analysis of their structure-activity relationship (SAR), a cyclopropyl analog 75 afforded from the structure of 74 not only displayed a low nanomole inhibitory effect (IC 50 = 8.5 nM), but also possessed reasonable aqueous solubility (0.12 mg/mL in buffer), excellent permeability, and orally bioavailability [182]

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Nasal and sublingual options Research into alternative delivery routes for GLP-1 agonists is ongoing