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However, metabolic disturbances (obesity, insulin resistance) and aging may convert PVAT into a source of inflammatory mediators, thereby accelerating arterial remodeling and contributing to the development of vascular stiffening

S., Richie, J

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These results, therefore, demonstrate that the loss of the diurnal rhythm of volume voided per micturition in ADx + CORT mice was an independent phenomenon distinct from the rhythms of urine production or activity