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The activation of MMP-2, MMP-3, and MMP-9 compromises key structural components, including the basement membrane, tight junctions, and extracellular matrix, thereby in-creasing BBB permeability

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It could be expected that in the case of more rigid pentamenthine dyes, this effect may not be as strong as in the case of more flexible heptamethine dyes

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Astragalus polysaccharide ameliorates renal inflammatory responses in a diabetic nephropathy by suppressing the TLR4/NF-B pathway