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Institute of Medicines Recommendations In their 1998 report, the IOM used the amount of B12 required to treat pernicious anemia as a basis for their recommendations for the general adult population (IOM, 1998)

This allows the reconstituted solution to remain stable for approximately 30 days when refrigerated

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B12-deficiency anemia can cause further complications, such as: difficulty walking uncontrollable muscle movements changes in smell or taste unintentional weight loss bleeding infection permanent brain or nerve damage B12 deficiency and anemia There are Diet: A person whose diet does not contain enough B12 can develop a deficiency after around 3 years, after which the body may begin to run out of stored B12