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Courtney-Martin G, Rafii M, Wykes LJ, Ball RO, Pencharz PB

7 Bruggeman et al conducted a placebo controlled trial using an orobuccal route for glutathione absorption thereby seeking to increase blood levels
When semaglutide binds to GLP-1 receptors in the brain, it reduces appetite and increases feelings of fullness

Further DBPC studies using biomarkers of metabolic pathways related to BH 4 metabolism will be needed to determine which children with ASD will most benefit from formulations of BH 4 supplementation like sapropterin

2014;40 doi: 10.1111/apt.12878
