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These findings have led to the disinhibition hypothesis, which states that BDZs and opioids exert their rewarding effects via disinhibition of GABAergic interneurons within the VTA, thus leading to an increase in DA release into the NAc, a major substrate for motivated behavior

Causes of MCAS include: Chronic bacterial infections, such as Lyme disease, Babesia, and Bartonella Chronic viral infections, such as Epstein-Barr Virus and Long COVID Mold illness & fungal infections Heavy metals Environmental toxins, such as herbicides & pesticides SIBO and leaky gut syndrome Allergens food and environmental Genetically predisposed Additionally, certain triggers cause mast cells to degranulate and release mediators in susceptible individuals

No, not as a primary effect

Consult witha veterinarian before using this product, especially in case of pre-existing conditions or using in addition to other supplements to avoid over dosage

[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Krischak G.D., Augat P., Claes L., Kinzl L., Beck A