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Many potential effectors can exist in several forms and chemical synthesis may lead to the production of, for example, mixtures of different racemates or diastereoisomers, some of which may be pharmaceutically effective, but others of which may cause deleterious effects such as what occurred with thalidomide

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2.2.3 Metabolic interplay and plasticity between de novo synthesis and exogenous uptake Intracellular synthesis and extracellular uptake constitute two primary pathways for serine acquisition in cancer cells, operating independently yet synergistically to sustain tumor metabolism

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