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While high-dose exogenous TNF mainly induces tumor cell apoptosis, endogenous low-concentration TNF derived from tumor cell or tumor microenvironment contrarily plays an oncogenic role

10.1016/j.chembiol.2020.03.014 11 BelavgeniA.MeyerC.StumpfJ.HugoC.LinkermannA

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Examples include: F1 reduces melanocyte dendricity and interferes with melanosome transfer to keratinocytes, producing visible lightening Rf suppresses CREB/MITF signaling and lowers tyrosinase activity, inhibiting melanin synthesis Rb2 down-regulates MITF and tyrosinase expression, again reducing melanogenesis Re inhibits melanin production in melanoma cells and shows anti-pigment effects in experimental systems Rg3 destroys MITF (the pigment on-switch), effectively telling the cell to stop producing color