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First, SFN stands as a exemplary multi-targeted agent whose pleiotropic mechanismsspanning epigenetic regulation, induction of specialized cell death programs, immunomodulation, and CSC targetingprovide a robust foundation for its efficacy against heterogeneous and treatment-resistant malignancies

(V) presence of antibodies directed against surface antigens on RBCs, such as antibodies anti-A, or anti-B blood group antigens (formed as a consequence of transfusion of allogenic blood from the wrong blood group), or autoimmune antibodies resulting in enhanced damage of RBC membranes (14, 92, 124, 160, 164, 178)

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