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Nitroprusside interacts with hemoglobin leading to the release of nitric oxide and cyanide, and the formation of methemoglobin [ferric iron (Fe 3+ ) containing hemoglobin]

10.1186/s12943-017-0648-1 150 ZhouJ.LiX

To determine whether dysregulated hepatic glutathione homeostasis and TNF can synergistically contribute to hepatocyte death, we performed cell culture studies using both human hepatoma cells and mouse non-transformed hepatocytes

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These environmental factors may induce epigenetic modifications, which connect changed patterns of gene expression to their surroundings