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In contrast, supplementing the diets of older mice with the NAD + -synthesizing precursors nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) replenished NAD + to levels observed in younger mice [149, 150]
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Available from: [DOI] [PubMed] [Google Scholar] 201.Hu N, Han X, Lane EK, Gao F, Zhang Y, Ren J

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The decrease in Nrf2 first leads to an increase of unbound Keap1, due to the reduced complex formation with Nrf2 (Fig 3C
